rs3856806

A SNP in the PPARG gene on chromosome 3. Its most notable genotype is C;C: common in clinvar

Gene
PPARG
Location
Chr 312,434,058 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
12%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.078% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 78%
  • European ancestry (Utah)C;C 80%
  • Han Chinese (Beijing)C;C 56%
  • Japanese (Tokyo)C;C 69%
  • Yoruba (Nigeria)C;C 92%
  • African ancestry (Southwest US)C;C 89%
  • Chinese (Denver)C;C 60%
  • Gujarati IndianC;C 72%
  • Luhya (Kenya)C;C 92%
  • Maasai (Kenya)C;C 85%
  • TuscanC;C 85%

Notes

From SNPedia

Show notes, about 470 words

Variations in the peroxisome proliferator-activated receptor-gamma gene and melanoma risk. PPAR-gamma gene polymorphisms and psoriatic arthritis. The Genetics of PPARG and the Skeleton. The association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma gene with serum osteoprotegerin levels in healthy Korean women. Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia. Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China. PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease. Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression. Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response. Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. PPARG by dietary fat interaction influences bone mass in mice and humans. Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population. Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. Genetic Variability of RXRB, PPARA, and PPARG in Wegener's Granulomatosis. Association and interaction of PPAR-complex gene variants with latent traits of left ventricular diastolic function. Joint effect of peroxisome proliferator-activated receptor gamma genetic polymorphisms and estrogen-related risk factors on breast cancer risk: results from a case-control study in Taiwan. Variants of the human PPARG locus and the susceptibility to chronic periodontitis. PPARG gene promoter polymorphism is associated with non-traumatic hip fracture risk in the elderly Slovenian population: a pilot study. Application of back propagation artificial neural network on genetic variants in adiponectin ADIPOQ, peroxisome proliferator-activated receptor-gamma, and retinoid X receptor-alpha genes and type 2 diabetes risk in a Chinese Han population. Association of PPAR-gamma gene polymorphisms with obesity and obesity-associated phenotypes in north indian population.

Source and license

Adapted from rs3856806 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.