rs2295490

A SNP in the TRIB3 gene on chromosome 20. Its most notable genotype is A;G: 1.32x increased risk of early-onset type-2 diabetes

Gene
TRIB3
Location
Chr 20388,261 (GRCh38)
Highest magnitude
1.3Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalMinor · 1.067% of people
  2. A;GMost notableBad1.32x increased risk of early-onset type-2 diabetesMinor · 1.330% of people
  3. G;GBad1.32x increased risk of early-onset type-2 diabetesMinor · 1.33% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 67% A;G 30% G;G 3%
  • European ancestry (Utah)A;A 77% A;G 21% G;G 3%
  • Han Chinese (Beijing)A;A 60% A;G 36% G;G 5%
  • Japanese (Tokyo)A;A 56% A;G 39% G;G 5%
  • Yoruba (Nigeria)A;A 73% A;G 24% G;G 3%
  • African ancestry (Southwest US)A;A 72% A;G 28% G;G 0%
  • Chinese (Denver)A;A 71% A;G 27% G;G 3%
  • Gujarati IndianA;A 39% A;G 49% G;G 12%
  • Luhya (Kenya)A;A 68% A;G 29% G;G 3%
  • Mexican ancestry (Los Angeles)A;A 91% A;G 9% G;G 0%
  • Maasai (Kenya)A;A 58% A;G 38% G;G 5%
  • TuscanA;A 70% A;G 29% G;G 1%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2295490 is a SNP in the tribbles homolog 3 TRIB3 gene, also known as Q84R. The (A) allele encodes the Gln (Q), while the (G) allele encodes the Arg (R). A study involving four different case-control samples comprising a total of 5469 Caucasisans determined that rs2295490(G) was nominally associated with type-2 diabetes (odds ratio 1.17, CI: 1.00-1.36, p = 0.04). When stratified by age of diabetes onset, these carriers had an increased risk of early-onset T2D (OR 1.32, CI: 1.10-1.58, p = 0.002). this gain of function mutation may affect insulin signaling and increase the risk of insulin resistance

A;A

Normal risk of early-onset type II diabetes

Source and license

Adapted from rs2295490 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.