rs4655595

A SNP in the PDE4B gene on chromosome 1. Its most notable genotype is A;A: normal

Gene
PDE4B
Location
Chr 166,093,076 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
18%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.059% of people
  2. A;GNot rated1.4 riskTypical · 0.035% of people
  3. G;GNot rated2.3 riskTypical · 0.06% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 59% A;G 35% G;G 6%
  • European ancestry (Utah)A;A 80% A;G 20% G;G 0%
  • Han Chinese (Beijing)A;A 47% A;G 47% G;G 7%
  • Japanese (Tokyo)A;A 44% A;G 45% G;G 11%
  • Yoruba (Nigeria)A;A 71% A;G 29% G;G <1%
  • African ancestry (Southwest US)A;A 67% A;G 33% G;G 0%
  • Chinese (Denver)A;A 49% A;G 41% G;G 10%
  • Gujarati IndianA;A 48% A;G 42% G;G 11%
  • Luhya (Kenya)A;A 59% A;G 32% G;G 9%
  • Mexican ancestry (Los Angeles)A;A 66% A;G 35% G;G 0%
  • Maasai (Kenya)A;A 44% A;G 46% G;G 11%
  • TuscanA;A 81% A;G 16% G;G 3%

Conditions, medicines and genes

Other PDE4B SNPs

All PDE4B SNPs

Notes

From SNPedia

Notes

rs4655595 has been reported in a large study to be associated with type-2 diabetes. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.37 (CI 1.17-1.59), and for homozygotes, 2.33 (CI 1.23-4.42).

A;A

increased risk of type-2 diabetes

Source and license

Adapted from rs4655595 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.