rs1321172

A SNP in the PDE4B gene on chromosome 1. Its most notable genotype is G;G: common

Gene
PDE4B
Location
Chr 166,265,030 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
33%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedcommonTypical · 0.09% of people
  2. C;GNot rated1.08x riskTypical · 0.033% of people
  3. C;CBad>1.08x riskTypical · 0.058% of people

SNPedia records rs1321172 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 9% C;G 33% C;C 58%
  • European ancestry (Utah)G;G 32% C;G 46% C;C 22%
  • Han Chinese (Beijing)G;G 4% C;G 28% C;C 68%
  • Japanese (Tokyo)G;G <1% C;G 15% C;C 84%
  • Yoruba (Nigeria)G;G 3% C;G 21% C;C 76%
  • African ancestry (Southwest US)G;G 4% C;G 46% C;C 51%
  • Chinese (Denver)G;G 3% C;G 32% C;C 65%
  • Gujarati IndianG;G 15% C;G 39% C;C 46%
  • Luhya (Kenya)G;G <1% C;G 28% C;C 72%
  • Mexican ancestry (Los Angeles)G;G 5% C;G 49% C;C 46%
  • Maasai (Kenya)G;G <1% C;G 19% C;C 81%
  • TuscanG;G 29% C;G 44% C;C 27%

Conditions, medicines and genes

Other PDE4B SNPs

All PDE4B SNPs

Notes

From SNPedia

Notes

rs1321172 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with this allele is 1.08 (CI 1.02-1.14).

Source and license

Adapted from rs1321172 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.