rs3816873

A SNP in the MTTP gene on chromosome 4. Its most notable genotype is C;C: reduced risk of type-2 diabetes

Gene
MTTP
Location
Chr 499,583,507 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodreduced risk of type-2 diabetesWorth knowing · 2.27% of people
  2. C;TNot ratedNo summary available.Typical · 0.035% of people
  3. T;TGoodNo summary available.Typical · 0.059% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 7% C;T 35% T;T 59%
  • European ancestry (Utah)C;C 5% C;T 41% T;T 54%
  • Han Chinese (Beijing)C;C <1% C;T 20% T;T 80%
  • Japanese (Tokyo)C;C 3% C;T 24% T;T 74%
  • Yoruba (Nigeria)C;C 6% C;T 34% T;T 60%
  • African ancestry (Southwest US)C;C 5% C;T 40% T;T 54%
  • Chinese (Denver)C;C 3% C;T 21% T;T 76%
  • Gujarati IndianC;C 15% C;T 37% T;T 48%
  • Luhya (Kenya)C;C 11% C;T 40% T;T 49%
  • Mexican ancestry (Los Angeles)C;C 7% C;T 29% T;T 64%
  • Maasai (Kenya)C;C 14% C;T 46% T;T 40%
  • TuscanC;C 3% C;T 50% T;T 47%

Conditions, medicines and genes

Other MTTP SNPs

All MTTP SNPs

Notes

From SNPedia

Notes

Also known as I128T MTP rare allele of the MTP I128T polymorphism may be protective against impaired glucose tolerance, type-2 diabetes Association of polymorphisms in glutamate-cysteine ligase catalytic subunit and microsomal triglyceride transfer protein genes with nonalcoholic fatty liver disease.

Source and license

Adapted from rs3816873 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.