rs146064714

A SNP in the MTTP gene on chromosome 4. Its most notable genotype is T;T: Apolipoproteinemia (predicted)

Gene
MTTP
Location
Chr 499,622,756 (GRCh38)
Highest magnitude
6.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. G;TBadCarrier of an apolipoproteinemia variantImportant · 3.0
  3. T;TMost notableBadApolipoproteinemia (predicted)Very important · 6.0

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other MTTP SNPs

All MTTP SNPs

Notes

From SNPedia

Notes

aka c.2593G>T, p.Gly865Ter and G865X With a carrier frequency of 1 in 131 among Ashkenazi Jews, the recessively inherited rs146064714(T) variant is the basis of an incidence rate for abetalipoproteinemia of about 1 in 70,000 in this population. It is at least 10 fold rarer in other populations.

G;T

Unaffected in absence of a second mutation in the MTTP gene.

T;T

see discussion on main rs-page; note that treatment with Vitamin E is often recommended.

Source and license

Adapted from rs146064714 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.