rs725613

A SNP in the CLEC16A gene on chromosome 16. Its most notable genotype is T;T: 1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis risk

Gene
CLEC16A
Location
Chr 1611,075,826 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
37%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis riskTypical · 0.037% of people
  2. G;TBad1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis riskTypical · 0.043% of people
  3. G;GNot ratednormalTypical · 0.020% of people

SNPedia records rs725613 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 37% G;T 43% G;G 20%
  • European ancestry (Utah)T;T 46% G;T 43% G;G 11%
  • Han Chinese (Beijing)T;T 51% G;T 47% G;G 2%
  • Japanese (Tokyo)T;T 67% G;T 30% G;G 3%
  • Yoruba (Nigeria)T;T 10% G;T 46% G;G 44%
  • African ancestry (Southwest US)T;T 18% G;T 42% G;G 40%
  • Chinese (Denver)T;T 56% G;T 37% G;G 7%
  • Gujarati IndianT;T 31% G;T 46% G;G 24%
  • Luhya (Kenya)T;T 17% G;T 46% G;G 37%
  • Mexican ancestry (Los Angeles)T;T 55% G;T 41% G;G 3%
  • Maasai (Kenya)T;T 20% G;T 51% G;G 30%
  • TuscanT;T 32% G;T 46% G;G 22%

Conditions, medicines and genes

Other CLEC16A SNPs

All CLEC16A SNPs

Notes

From SNPedia

Show notes, about 130 words

associated with type-1 diabetes In a separate study, Sardinians with either type-1 diabetes (1,037 patients) or multiple sclerosis (1,498 patients) plus matched controls were genotyped for rs725613. In this study, the rs725613(A) allele was positively associated not only with type-1 diabetes (odds ratio 1.15, p = 5.1 x 10e-3) but also with multiple sclerosis (odds ratio = 1.21, p = 6.7 x 10e-5). rs725613 was strongly associated with T1D in the Han Chinese population (P = 0.00007, odds ratio (OR) = 0.527, 95% confidence interval (CI) = 0.383-0.726) Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

Source and license

Adapted from rs725613 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.