rs6498169

A SNP in the CLEC16A gene on chromosome 16. Its most notable genotype is A;A: >1.14x risk of multiple sclerosis

Gene
CLEC16A
Location
Chr 1611,155,472 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
40%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad>1.14x risk of multiple sclerosisWorth knowing · 2.043% of people
  2. A;GBad1.14x risk of multiple sclerosisMinor · 1.540% of people
  3. G;GNot ratedcommonTypical · 0.017% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageA;A 43% A;G 40% G;G 17%
  • European ancestry (Utah)A;A 38% A;G 46% G;G 17%
  • Han Chinese (Beijing)A;A 20% A;G 51% G;G 29%
  • Japanese (Tokyo)A;A 19% A;G 50% G;G 31%
  • Yoruba (Nigeria)A;A 65% A;G 29% G;G 6%
  • African ancestry (Southwest US)A;A 50% A;G 46% G;G 4%
  • Gujarati IndianA;A 59% A;G 34% G;G 7%
  • Mexican ancestry (Los Angeles)A;A 19% A;G 43% G;G 38%
  • Maasai (Kenya)A;A 70% A;G 24% G;G 6%
  • TuscanA;A 48% A;G 38% G;G 14%

Conditions, medicines and genes

Other CLEC16A SNPs

All CLEC16A SNPs

Notes

From SNPedia

Notes

rs6498169 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with this allele is 1.14 (CI 1.08-1.21).

Source and license

Adapted from rs6498169 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.