rs12708716

A SNP in the CLEC16A gene on chromosome 16. Its most notable genotype is A;A: 1.6x risk of type-1 diabetes

Gene
CLEC16A
Location
Chr 1611,086,016 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.6x risk of type-1 diabetesTypical · 0.041% of people
  2. A;GBad1.2x risk of type-1 diabetesTypical · 0.044% of people
  3. G;GNot ratednormalTypical · 0.015% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 41% A;G 44% G;G 15%
  • European ancestry (Utah)A;A 47% A;G 43% G;G 11%
  • Han Chinese (Beijing)A;A 50% A;G 47% G;G 2%
  • Japanese (Tokyo)A;A 71% A;G 27% G;G 3%
  • Yoruba (Nigeria)A;A 31% A;G 48% G;G 21%
  • African ancestry (Southwest US)A;A 32% A;G 46% G;G 23%
  • Chinese (Denver)A;A 51% A;G 42% G;G 7%
  • Gujarati IndianA;A 31% A;G 46% G;G 24%
  • Luhya (Kenya)A;A 31% A;G 44% G;G 26%
  • Mexican ancestry (Los Angeles)A;A 53% A;G 43% G;G 3%
  • Maasai (Kenya)A;A 28% A;G 49% G;G 23%
  • TuscanA;A 32% A;G 46% G;G 22%

Conditions, medicines and genes

Other CLEC16A SNPs

All CLEC16A SNPs

Notes

From SNPedia

Notes

rs12708716 has been reported in a large study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.19 (CI 0.97-1.45), and for homozygotes, 1.55 (CI 1.27-1.89). In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 0.81 (CI 0.77-0.86). Tested in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10 296 unrelated controls, SNP rs12708716 was associated with disease risk (p = 1.6 x 10e-16)

Source and license

Adapted from rs12708716 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.