rs17166496

A SNP in the FSTL4 gene on chromosome 5. Its most notable genotype is C;C: 1.1x risk for type-1 diabetes

Gene
FSTL4
Location
Chr 5133,293,192 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.1x risk for type-1 diabetesTypical · 0.019% of people
  2. C;GBad0.8x risk for type-1 diabetesTypical · 0.046% of people
  3. G;GNot ratednormalTypical · 0.035% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 19% C;G 46% G;G 35%
  • European ancestry (Utah)C;C 35% C;G 48% G;G 18%
  • Han Chinese (Beijing)C;C 14% C;G 33% G;G 53%
  • Japanese (Tokyo)C;C 11% C;G 43% G;G 47%
  • Yoruba (Nigeria)C;C 13% C;G 48% G;G 40%
  • African ancestry (Southwest US)C;C 19% C;G 42% G;G 39%
  • Chinese (Denver)C;C 9% C;G 40% G;G 52%
  • Gujarati IndianC;C 19% C;G 57% G;G 24%
  • Luhya (Kenya)C;C 16% C;G 49% G;G 36%
  • Mexican ancestry (Los Angeles)C;C 26% C;G 47% G;G 28%
  • Maasai (Kenya)C;C 15% C;G 49% G;G 35%
  • TuscanC;C 38% C;G 49% G;G 13%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs17166496 has been reported in a large study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 0.77 (CI 0.68-0.87), and for homozygotes, 1.09 (CI 0.92-1.29). Note: orientation of SNP is presumed correct but should be confirmed

Source and license

Adapted from rs17166496 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.