rs763361

A SNP in the CD226 gene on chromosome 18. Its most notable genotype is T;T: Increased risk for multiple autoimmune diseases

Gene
CD226
Location
Chr 1869,864,406 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNormal risk for multiple autoimmune diseasesMinor · 1.021% of people
  2. C;TBadSlightly increased risk for multiple autoimmune diseases, such as type-1 diabetesMinor · 1.548% of people
  3. T;TMost notableBadIncreased risk for multiple autoimmune diseasesWorth knowing · 2.032% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 21% C;T 48% T;T 32%
  • European ancestry (Utah)C;C 25% C;T 51% T;T 24%
  • Han Chinese (Beijing)C;C 37% C;T 53% T;T 10%
  • Japanese (Tokyo)C;C 27% C;T 56% T;T 17%
  • Yoruba (Nigeria)C;C 3% C;T 46% T;T 51%
  • African ancestry (Southwest US)C;C 5% C;T 60% T;T 35%
  • Chinese (Denver)C;C 40% C;T 51% T;T 9%
  • Gujarati IndianC;C 19% C;T 45% T;T 37%
  • Luhya (Kenya)C;C 8% C;T 39% T;T 53%
  • Mexican ancestry (Los Angeles)C;C 27% C;T 45% T;T 29%
  • Maasai (Kenya)C;C 8% C;T 37% T;T 55%
  • TuscanC;C 28% C;T 45% T;T 28%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

rs763361, also known as Gly307Ser, is a SNP in the immune response CD226 gene. The rs763361(T) allele (in dbSNP orientation) encodes the Ser. Based on multiple studies (by one group) now totaling over 2,000 patients, the rs763361(T) allele is associated with increased risk for multiple autoimmune diseases, including type-1 diabetes (p = 3 x 10e-9), multiple sclerosis (p = 4 x 10e-4), and possibly rheumatoid arthritis (p = 0.017). Based on tag SNP analysis, the authors conclude that this SNP could be the causal variant. Tested in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10 296 unrelated controls, SNP rs763361 was associated with disease risk (p = 5.4 x 10e-8)

C;T

Higher risk of type-1 diabetes.

Source and license

Adapted from rs763361 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.