rs2544677

A SNP on chromosome 5. Its most notable genotype is G;G: normal

Gene
None listed
Location
Chr 587,103,445 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
12%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.02% of people
  2. C;GBad1.3x risk of type-1 diabetesTypical · 0.018% of people
  3. C;CBad1.7x risk of type-1 diabetesTypical · 0.080% of people

SNPedia records rs2544677 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 2% C;G 18% C;C 80%
  • European ancestry (Utah)G;G 4% C;G 42% C;C 54%
  • Han Chinese (Beijing)G;G 0% C;G 2% C;C 98%
  • Japanese (Tokyo)G;G 0% C;G 0% C;C 100%
  • Yoruba (Nigeria)G;G 0% C;G 8% C;C 93%
  • African ancestry (Southwest US)G;G 0% C;G 7% C;C 93%
  • Gujarati IndianG;G 2% C;G 26% C;C 72%
  • Luhya (Kenya)G;G 0% C;G 10% C;C 90%
  • Mexican ancestry (Los Angeles)G;G 5% C;G 22% C;C 72%
  • Maasai (Kenya)G;G 3% C;G 25% C;C 72%
  • TuscanG;G 2% C;G 42% C;C 56%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2544677 has been reported in a large study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.34 (CI 1.00-1.79), and for homozygotes, 1.65 (CI 1.24-2.18).

Source and license

Adapted from rs2544677 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.