rs11171739

A SNP in the ERBB3 gene on chromosome 12. Its most notable genotype is C;C: 1.75x risk of developing Type-1 diabetes

Gene
ERBB3
Location
Chr 1256,076,841 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNo summary available.Typical · 0.00% of people
  2. C;CMost notableBad1.75x risk of developing Type-1 diabetesWorth knowing · 2.026% of people
  3. C;TBad1.34x risk of developing Type-1 diabetesMinor · 1.539% of people
  4. T;TGoodNormal risk of developing Type-1 diabetesMinor · 1.035% of people

On SNPedia: (A;A), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 0% C;C 26% C;T 39% T;T 35%
  • European ancestry (Utah)A;A 0% C;C 17% C;T 48% T;T 35%
  • Han Chinese (Beijing)A;A 0% C;C 7% C;T 37% T;T 56%
  • Japanese (Tokyo)A;A 0% C;C 3% C;T 43% T;T 54%
  • Yoruba (Nigeria)A;A 0% C;C 73% C;T 25% T;T 3%
  • African ancestry (Southwest US)A;A 0% C;C 53% C;T 40% T;T 7%
  • Chinese (Denver)A;A 0% C;C 7% C;T 35% T;T 58%
  • Gujarati IndianA;A 0% C;C 9% C;T 33% T;T 58%
  • Luhya (Kenya)A;A 0% C;C 71% C;T 26% T;T 3%
  • Mexican ancestry (Los Angeles)A;A 0% C;C 9% C;T 40% T;T 52%
  • Maasai (Kenya)A;A 0% C;C 32% C;T 47% T;T 21%
  • TuscanA;A 0% C;C 12% C;T 52% T;T 36%

Conditions, medicines and genes

Other ERBB3 SNPs

All ERBB3 SNPs

Notes

From SNPedia

Notes

rs11171739 has been reported in a large study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.34 (CI 1.17-1.54), and for homozygotes, 1.75 (CI 1.48-2.06). In an expanded follow-up study of >6,000 controls and 6,000 patients, in which rs2292239 was ultimately chosen to replace the nearby rs11171739 originally determined to be associated with type-1 diabetes, the heterozygote odds ratio for SNP rs11171739 was recalculated to be 1.22 (CI 1.17–1.29).

Source and license

Adapted from rs11171739 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.