rs2292239

A SNP in the ERBB3 gene on chromosome 12. Its most notable genotype is T;T: 1.7x risk

Gene
ERBB3
Location
Chr 1256,088,396 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot rated1.7x riskTypical · 0.011% of people
  2. G;TBad1.3x riskTypical · 0.040% of people
  3. G;GNot ratednormalTypical · 0.049% of people
  4. A;ANot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs2292239 on the minus strand: (A;A), (A;C), (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 11% G;T 40% G;G 49% A;A 0%
  • European ancestry (Utah)T;T 13% G;T 41% G;G 46% A;A 0%
  • Han Chinese (Beijing)T;T 6% G;T 37% G;G 57% A;A 0%
  • Japanese (Tokyo)T;T 3% G;T 42% G;G 56% A;A 0%
  • Yoruba (Nigeria)T;T 20% G;T 50% G;G 29% A;A 0%
  • African ancestry (Southwest US)T;T 16% G;T 40% G;G 44% A;A 0%
  • Chinese (Denver)T;T 7% G;T 28% G;G 64% A;A 0%
  • Gujarati IndianT;T 7% G;T 26% G;G 67% A;A 0%
  • Luhya (Kenya)T;T 24% G;T 53% G;G 24% A;A 0%
  • Mexican ancestry (Los Angeles)T;T 5% G;T 33% G;G 62% A;A 0%
  • Maasai (Kenya)T;T 12% G;T 47% G;G 41% A;A 0%
  • TuscanT;T 8% G;T 46% G;G 46% A;A 0%

Conditions, medicines and genes

Other ERBB3 SNPs

All ERBB3 SNPs

Notes

From SNPedia

Notes

In an expanded follow-up study of >6,000 controls and 6,000 patients, in which rs2292239 was chosen to replace the nearby rs11171739 originally determined to be associated with type-1 diabetes, the heterozygote odds ratio for this SNP was recalculated to be 1.28 (CI 1.20 - 1.36).

Source and license

Adapted from rs2292239 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.