rs6679677

rs6679677 has been reported in a large study to be associated with rheumatoid arthritis. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.98 (CI 1.72-2.27), and for homozygotes, 3.32 (CI 1.93-5.69). rs6679677 was also reported in the same study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.82 (CI 1.59-2.09), and for homozygotes, 5.19 (CI 3.15-8.55). Recently (Feb 2008), it has been asserted that the association between rs6679677 and type-1 diabetes is actually completely due to a closely linked, potentially causal variant identified as rs2476601, which is also known as Arg620Trp. In this study, apparently the largest to date, the odds ratio for the risk allele (of rs6679677) was reported to be 1.88 (CI: 1.66-2.13). DeCode reports that the CC genotype is associated with 1.05x higher odds of Crohn's disease. Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. Genome-wide association studies: progress and potential for drug discovery and development. Worldwide population differentiation at disease-associated SNPs. Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Type 1 diabetes in the BB rat: a polygenic disease. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases. Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis. Allelic variants in the PHTF1-PTPN22, C12orf30 and CD226 regions as candidate susceptibility factors for the type 1 diabetes in the Estonian population. The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1. Novel association strategy with copy number variation for identifying new risk Loci of human diseases.

A;A

5.2x risk for type-1 diabetes 3.3x risk for rheumatoid arthritis

A;C

1.8x risk for type-1 diabetes 2x risk for rheumatoid arthritis