rs3789604

A SNP in the RSBN1 gene on chromosome 1. Its most notable genotype is G;G: 1.7x increased RA risk

Gene
RSBN1
Location
Chr 1113,812,320 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.7x increased RA riskTypical · 0.05% of people
  2. G;TBad1.5x increased RA risk; 1.4x increased GD riskTypical · 0.023% of people
  3. T;TNot ratednormal for RA; 1.4x increased GD riskTypical · 0.072% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 5% G;T 23% T;T 72%
  • European ancestry (Utah)G;G 7% G;T 25% T;T 68%
  • Han Chinese (Beijing)G;G 8% G;T 26% T;T 66%
  • Japanese (Tokyo)G;G 5% G;T 36% T;T 59%
  • Yoruba (Nigeria)G;G 0% G;T 5% T;T 95%

Conditions, medicines and genes

Other RSBN1 SNPs

All RSBN1 SNPs

Notes

From SNPedia

Notes

rs3789604 is associated with increased susceptibility to rheumatoid arthritis, based on a study of ~1,000 Caucasian individuals. The odds ratio is 1.55x for (G;T) heterozygotes and 1.73x for (G;G) homozygotes. However, in a Japanese population, the other allele, rs3789604(T), is associated with increased risk (odds ratio 1.45, p=0.0085) for Graves' disease (GD).

Source and license

Adapted from rs3789604 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.