rs689

A strong association between rs689, a SNP within the insulin INS gene, has been reported with type-1 diabetes Several studies (including ) have mentioned replicating this result, although without mentioning specific risk odds. The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults. A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels. The TCF7L2 locus and type 1 diabetes. Association between small for gestational age and paternally inherited 5' insulin haplotypes. Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease. On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes. Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes. Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1). Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese. Genotype score in addition to common risk factors for prediction of type 2 diabetes. Shared and distinct genetic variants in type 1 diabetes and celiac disease. Type 1 diabetes in the BB rat: a polygenic disease. Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes? Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth. The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome. A strategy for analyzing gene-nutrient interactions in type 2 diabetes. Allele-specific recognition of the 3' splice site of INS intron 1. Genetic risk profiling for prediction of type 2 diabetes. Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.