rs11052552

A SNP in the LOC105369652 gene on chromosome 12. Its most notable genotype is G;G: 1.4x risk of type-1 diabetes

Gene
LOC105369652
Location
Chr 129,703,362 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.4x risk of type-1 diabetesTypical · 0.021% of people
  2. G;TBad1.5x risk of type-1 diabetesTypical · 0.041% of people
  3. T;TNot ratednormalTypical · 0.038% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 21% G;T 41% T;T 38%
  • European ancestry (Utah)G;G 32% G;T 46% T;T 22%
  • Han Chinese (Beijing)G;G 44% G;T 47% T;T 10%
  • Japanese (Tokyo)G;G 38% G;T 50% T;T 12%
  • Yoruba (Nigeria)G;G 3% G;T 31% T;T 67%
  • African ancestry (Southwest US)G;G 0% G;T 47% T;T 53%
  • Chinese (Denver)G;G 39% G;T 50% T;T 11%
  • Gujarati IndianG;G 26% G;T 50% T;T 24%
  • Luhya (Kenya)G;G 0% G;T 15% T;T 85%
  • Mexican ancestry (Los Angeles)G;G 29% G;T 52% T;T 19%
  • Maasai (Kenya)G;G <1% G;T 22% T;T 78%
  • TuscanG;G 21% G;T 46% T;T 33%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs11052552 has been reported in a large study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.49 (CI 1.28-1.73), and for homozygotes, 1.43 (CI 1.21-1.69).

Source and license

Adapted from rs11052552 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.