rs6822844

association with rheumatoid arthritis and type-1 diabetes point to a general risk locus for autoimmune diseases. Also, of SNPs outside the HLA region, this SNP and one other (rs13119723) in the region of the IL21 gene showed the strongest association with celiac disease in a study of ~800 Caucasian patients and a meta-analysis of two further populations. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families. Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Shared and distinct genetic variants in type 1 diabetes and celiac disease. Genome-wide association analysis by lasso penalized logistic regression. Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations. Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis. Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus. Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk. Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment. Consolidation of evidence for association of the KIAA1109-TENR-IL2-IL21 rs6822844 variant with Crohn's disease. Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis. A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients.