rs17388568

A SNP in the ADAD1 gene on chromosome 4. Its most notable genotype is A;A: 1.6x risk of type-1 diabetes

Gene
ADAD1
Location
Chr 4122,408,207 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.6x risk of type-1 diabetesTypical · 0.02% of people
  2. A;GBad1.3x risk of type-1 diabetesTypical · 0.023% of people
  3. G;GNot ratednormalTypical · 0.075% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 2% A;G 23% G;G 75%
  • European ancestry (Utah)A;A 10% A;G 50% G;G 41%
  • Han Chinese (Beijing)A;A 2% A;G 26% G;G 73%
  • Japanese (Tokyo)A;A 0% A;G 21% G;G 79%
  • Yoruba (Nigeria)A;A 0% A;G 1% G;G 99%
  • African ancestry (Southwest US)A;A 0% A;G 5% G;G 95%
  • Chinese (Denver)A;A <1% A;G 23% G;G 76%
  • Gujarati IndianA;A 2% A;G 26% G;G 72%
  • Luhya (Kenya)A;A 0% A;G 11% G;G 89%
  • Mexican ancestry (Los Angeles)A;A 2% A;G 22% G;G 76%
  • Maasai (Kenya)A;A 3% A;G 26% G;G 71%
  • TuscanA;A 5% A;G 37% G;G 58%

Conditions, medicines and genes

Other ADAD1 SNPs

All ADAD1 SNPs

Notes

From SNPedia

Notes

rs17388568 has been reported in a large study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.26 (CI 1.11-1.42), and for homozygotes, 1.58 (CI 1.27-1.95). In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.11 (CI 1.05&#226;&#8364;&#8220;1.18).

Source and license

Adapted from rs17388568 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.