rs2639703

A SNP in the ENAH gene on chromosome 1. Its most notable genotype is A;A.

Gene
ENAH
Location
Chr 1225,625,209 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
41%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. C;CNot rated1.6x riskTypical · 0.023% of people
  3. C;TNot rated1.1x riskTypical · 0.045% of people
  4. T;TNot ratednormalTypical · 0.032% of people

On SNPedia: (A;A), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 0% C;C 23% C;T 45% T;T 32%
  • European ancestry (Utah)A;A 0% C;C 7% C;T 42% T;T 51%
  • Han Chinese (Beijing)A;A 0% C;C 8% C;T 32% T;T 60%
  • Japanese (Tokyo)A;A 0% C;C 10% C;T 48% T;T 42%
  • Yoruba (Nigeria)A;A 0% C;C 53% C;T 43% T;T 4%
  • African ancestry (Southwest US)A;A 0% C;C 40% C;T 44% T;T 16%
  • Chinese (Denver)A;A 0% C;C 11% C;T 46% T;T 43%
  • Gujarati IndianA;A 0% C;C 37% C;T 47% T;T 17%
  • Luhya (Kenya)A;A 0% C;C 46% C;T 46% T;T 7%
  • Mexican ancestry (Los Angeles)A;A 0% C;C 16% C;T 47% T;T 38%
  • Maasai (Kenya)A;A 0% C;C 22% C;T 58% T;T 21%
  • TuscanA;A 0% C;C 8% C;T 44% T;T 48%

Conditions, medicines and genes

Other ENAH SNPs

All ENAH SNPs

Notes

From SNPedia

Notes

rs2639703 has been reported in a large study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.15 (CI 1.02-1.31), and for homozygotes, 1.61 (CI 1.31-1.99).

Source and license

Adapted from rs2639703 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.