rs7454108

A SNP on chromosome 6. Its most notable genotype is C;C: Homozygous for HLA-DQ8 haplotype

Gene
None listed
Location
Chr 632,713,706 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
10%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadHomozygous for HLA-DQ8 haplotypeMinor · 1.5<1% of people
  2. C;TBadSingle HLA-DQ8 haplotypeMinor · 1.515% of people
  3. T;TGoodcommon in complete genomicsTypical · 0.084% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C <1% C;T 15% T;T 84%
  • European ancestry (Utah)C;C 4% C;T 29% T;T 67%
  • Han Chinese (Beijing)C;C 0% C;T 12% T;T 88%
  • Japanese (Tokyo)C;C 2% C;T 19% T;T 80%
  • Yoruba (Nigeria)C;C 0% C;T 5% T;T 95%
  • African ancestry (Southwest US)C;C 0% C;T 14% T;T 86%
  • Chinese (Denver)C;C 0% C;T 12% T;T 88%
  • Gujarati IndianC;C 3% C;T 13% T;T 84%
  • Luhya (Kenya)C;C 0% C;T 5% T;T 96%
  • Mexican ancestry (Los Angeles)C;C 2% C;T 38% T;T 60%
  • Maasai (Kenya)C;C <1% C;T 15% T;T 85%
  • TuscanC;C 0% C;T 8% T;T 92%

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

People with the human leukocyte antigen (HLA) genotype DRB1*0301-DQA1*0501-DQB1*0201/DRB1*04-DQA1*0301-DQB1*0302 (more simply known as "DR3/4-DQ8") are at the highest risk of developing type-1 diabetes. The rs2040410(A) allele is associated with DRB1*0301, and the rs7454108(C) allele is associated with DQB1*0302 (and thus DQ8). Instead of more traditional antibody-based tests, two SNPs (rs2040410 and rs7454108) can be used to identify the presence or absence of the DR3/4-DQ8 genotype and thus the highest-risk heterozygous genotype associated with type-1 diabetes. For users of Promethease, this is determined via Gs121.

Source and license

Adapted from rs7454108 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.