rs17696736

A SNP in the NAA25 gene on chromosome 12. Its most notable genotype is G;G: 1.94x risk of type-1 diabetes

Gene
NAA25
Location
Chr 12112,049,014 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
20%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.074% of people
  2. A;GBad1.34x risk of type-1 diabetesWorth knowing · 2.021% of people
  3. G;GMost notableBad1.94x risk of type-1 diabetesWorth knowing · 2.56% of people
  4. T;TNot ratedNo summary available.Typical · 0.00% of people

On SNPedia: (A;A), (A;G), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageA;A 74% A;G 21% G;G 6% T;T 0%
  • European ancestry (Utah)A;A 42% A;G 45% G;G 13% T;T 0%
  • Han Chinese (Beijing)A;A 99% A;G <1% G;G 0% T;T 0%
  • Japanese (Tokyo)A;A 100% A;G 0% G;G 0% T;T 0%
  • Yoruba (Nigeria)A;A 100% A;G 0% G;G 0% T;T 0%
  • African ancestry (Southwest US)A;A 84% A;G 14% G;G 2% T;T 0%
  • Gujarati IndianA;A 78% A;G 20% G;G 2% T;T 0%
  • Mexican ancestry (Los Angeles)A;A 66% A;G 31% G;G 3% T;T 0%
  • TuscanA;A 23% A;G 54% G;G 24% T;T 0%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs17696736 has been reported in a large study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.34 (CI 1.16-1.53), and for homozygotes, 1.94 (CI 1.65-2.29). In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.22 (CI 1.15&#226;&#8364;&#8220;1.28).

Source and license

Adapted from rs17696736 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.