rs2488457(C;C)

Slightly increased (~1.7x) risk for certain autoimmune diseases in some populations

Magnitude
1.7Minor
Repute
Bad
Frequency
59%Average of 11 populations
On SNPedia
rs2488457(G;G)Minus strand
Gene
PTPN22

Frequency

Share of people with C;C in each HapMap population.

  • Yoruba (Nigeria)100%
  • Luhya (Kenya)96%
  • African ancestry (Southwest US)93%
  • Maasai (Kenya)87%
  • European ancestry (Utah)64%
  • Gujarati Indian62%
  • Tuscan61%
  • Mexican ancestry (Los Angeles)45%
  • Japanese (Tokyo)20%
  • Han Chinese (Beijing)11%
  • Chinese (Denver)8%

Other genotypes of rs2488457

  1. G;GGoodcommon/normalTypical · 0.014% of people
  2. C;GBadSlightly increased (~1.5x) risk for certain autoimmune diseases in some populationsMinor · 1.528% of people

All about rs2488457

Notes

From SNPedia

See discussion and citations via main rs-page

Source and license

Adapted from rs2488457(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.