rs2296336

A SNP in the ITPR3 gene on chromosome 6. Its most notable genotype is G;G: 2.9x risk of type-1 diabetes

Gene
ITPR3
Location
Chr 633,668,883 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad2.9x risk of type-1 diabetesTypical · 0.013% of people
  2. C;GBad1.3x risk of type-1 diabetesTypical · 0.049% of people
  3. C;CGoodnormalTypical · 0.039% of people

SNPedia records rs2296336 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 13% C;G 49% C;C 39%
  • European ancestry (Utah)G;G 11% C;G 46% C;C 43%
  • Han Chinese (Beijing)G;G 24% C;G 53% C;C 22%
  • Japanese (Tokyo)G;G 14% C;G 59% C;C 27%
  • Yoruba (Nigeria)G;G 2% C;G 36% C;C 63%

Conditions, medicines and genes

Other ITPR3 SNPs

All ITPR3 SNPs

Notes

From SNPedia

Notes

rs2296336 has been reported in a Swedish study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.3 (CI 1.00-1.69), and for homozygotes, 2.9 (CI 1.88-4.59). suggests this SNP does not play a direct role in type-1 diabetes, and was only seen in the previous study due to being in linkage disequilibrium with specific alleles of the HLA DQB1 gene.

Source and license

Adapted from rs2296336 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.