rs13293564

A SNP in the UNC13B gene on chromosome 9. Its most notable genotype is G;G: 1.63x increased nephropathy risk among type-1 diabetics

Gene
UNC13B
Location
Chr 935,166,766 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot rated1.63x increased nephropathy risk among type-1 diabeticsTypical · 0.049% of people
  2. G;TNot ratednormalTypical · 0.034% of people
  3. T;TNot ratednormalTypical · 0.017% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 49% G;T 34% T;T 17%
  • European ancestry (Utah)G;G 33% G;T 55% T;T 13%
  • Han Chinese (Beijing)G;G 97% G;T 3% T;T 0%
  • Japanese (Tokyo)G;G 98% G;T 2% T;T 0%
  • Yoruba (Nigeria)G;G 8% G;T 46% T;T 47%
  • African ancestry (Southwest US)G;G 9% G;T 51% T;T 40%
  • Chinese (Denver)G;G 97% G;T 3% T;T 0%
  • Gujarati IndianG;G 68% G;T 26% T;T 6%
  • Luhya (Kenya)G;G 17% G;T 51% T;T 32%
  • Mexican ancestry (Los Angeles)G;G 33% G;T 47% T;T 21%
  • Maasai (Kenya)G;G 42% G;T 42% T;T 17%
  • TuscanG;G 37% G;T 47% T;T 16%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2281999 and rs13293564 (G/T) diabetic nephropathy type-1 diabetes case/control (1176/1323) study from 3 European populations *odds ratio (OR) for DN associated with the TT genotype was 1.68 [95%CI, 1.29 - 2.19], p = 1.0 10(-4)) replicated in an independent population of 412 cases and 614 controls, (combined OR of 1.63 [CI: 1.30 - 2.05], p = 2.3 10(-5))

Source and license

Adapted from rs13293564 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.