rs660895

A SNP on chromosome 6. Its most notable genotype is G;G: 6x higher risk of rheumatoid arthritis

Gene
None listed
Location
Chr 632,609,603 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalTypical · 0.066% of people
  2. A;GBadpossibly at 4x higher risk of rheumatoid arthritisTypical · 0.030% of people
  3. G;GMost notableBad6x higher risk of rheumatoid arthritisWorth knowing · 2.54% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 66% A;G 30% G;G 4%
  • European ancestry (Utah)A;A 52% A;G 40% G;G 8%
  • Han Chinese (Beijing)A;A 64% A;G 33% G;G 4%
  • Japanese (Tokyo)A;A 50% A;G 40% G;G 10%
  • Yoruba (Nigeria)A;A 80% A;G 19% G;G <1%
  • African ancestry (Southwest US)A;A 67% A;G 30% G;G 4%
  • Chinese (Denver)A;A 60% A;G 37% G;G 4%
  • Gujarati IndianA;A 76% A;G 21% G;G 3%
  • Luhya (Kenya)A;A 86% A;G 15% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 45% A;G 45% G;G 10%
  • Maasai (Kenya)A;A 71% A;G 28% G;G 2%
  • TuscanA;A 77% A;G 22% G;G 2%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 180 words

This SNP, along with SNPs rs6910071 and rs3817964, is a tag SNP for the HLA-DRB1*0401 allele. The HLA-DRB1*0401 allele has been associated with higher risk for rheumatoid arthritis, and in particular, rheumatoid vasculitis. The association is seen particularly for individuals carrying two copies of, i.e. homozygous for, the allele. The reported odds ratio for rs660895(G;G) homozygotes is 6.2 (CI: 1.01 - 37.9). The risk for rheumatoid arthritis may be higher for individuals carrying one copy (one "dose") of the HLA-DRB1*0401 allele, if they also carry a different HLA-DRB1 risk allele. In particular, *0401/*0404 individuals are reported to have an odds ratio for rheumatoid vasculitis of 4.1 (CI: 1.1 - 16.2), and *0401/*0101 individuals have an odds ratio of 4.0 (CI: 1.4 - 11.6). *(A;A) is 0 dose of HLA-DRB1*0401 *(A;G) is 1 dose of HLA-DRB1*0401 rs660895 was found to be associated with rheumatoid arthritis based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.

Source and license

Adapted from rs660895 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.