rs1328674
A SNP in the HTR2A gene on chromosome 13. Its most notable genotype is T;T: higher risk for RA
- Gene
- HTR2A
- Location
- Chr 1346,867,572 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 5%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1328674 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T <1% C;T 9% C;C 90%
- European ancestry (Utah)T;T <1% C;T 6% C;C 93%
- Han Chinese (Beijing)T;T 0% C;T 8% C;C 92%
- Japanese (Tokyo)T;T 0% C;T 6% C;C 94%
- Yoruba (Nigeria)T;T <1% C;T 19% C;C 81%
- African ancestry (Southwest US)T;T 2% C;T 11% C;C 88%
- Chinese (Denver)T;T 0% C;T 7% C;C 93%
- Gujarati IndianT;T 0% C;T 4% C;C 96%
- Luhya (Kenya)T;T <1% C;T 14% C;C 85%
- Mexican ancestry (Los Angeles)T;T 0% C;T 7% C;C 93%
- Maasai (Kenya)T;T <1% C;T 9% C;C 90%
- TuscanT;T 0% C;T 10% C;C 90%
Related
Conditions, medicines and genes
Other HTR2A SNPs
- rs6311C;C3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants.Important
- rs6313A;Adepression, panic, stress responseWorth knowing
- rs6314G;Ghigher risk for RATypical
- rs594242C;GNo summary available.Typical
- rs643627A;GNo summary available.Typical
- rs659734A;Acommon in complete genomicsTypical
- rs2224721G;Gcommon/normalTypical
- rs7997012A;A~18% more likely to respond to citalopramTypical
Genosets
- Gs108Rheumatoid arthritis riskWorth knowing
- Gs109Rheumatoid arthritis risk; more stringent form of Gs108Worth knowing
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs1328674 is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs1328674(A) in dbSNP orientation. The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). This is actually quite close to the odds ratio calculated for rs1328674 by itself; OR of 1.62 (p = 0.007). Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above should be CACC, rather than CTCC as published.
Source and license
Adapted from rs1328674 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.