rs2224721
A SNP in the HTR2A gene on chromosome 13. Its most notable genotype is G;G: common/normal
- Gene
- HTR2A
- Location
- Chr 1346,858,019 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 32%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2224721 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 40%
- European ancestry (Utah)G;G 50%
- Han Chinese (Beijing)G;G 53%
- Japanese (Tokyo)G;G 30%
- Yoruba (Nigeria)G;G 26%
Related
Conditions, medicines and genes
Other HTR2A SNPs
- rs6311C;C3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants.Important
- rs6313A;Adepression, panic, stress responseWorth knowing
- rs6314G;Ghigher risk for RATypical
- rs594242C;GNo summary available.Typical
- rs643627A;GNo summary available.Typical
- rs659734A;Acommon in complete genomicsTypical
- rs1328674T;Thigher risk for RATypical
- rs7997012A;A~18% more likely to respond to citalopramTypical
Notes
From SNPedia
Notes
: "Haplotype association analysis suggests that the haplotype CCGCA (at SNPs rs3125, rs6314, rs1923886, rs2224721 and rs2770296) is protective against bipolar disorder (P = 0.021, odds ratio 0.63) and the rarer haplotype CCACG confers risk to the disorder (P = 0.0065, odds ratio 3.08)."
Source and license
Adapted from rs2224721 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.