rs643627

A SNP in the HTR2A gene on chromosome 13. Its most notable genotype is A;G.

Gene
HTR2A
Location
Chr 1346,854,476 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;GMost notableNot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs643627 on the minus strand: (T;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;G 0%
  • European ancestry (Utah)A;G 0%
  • Han Chinese (Beijing)A;G 0%
  • Japanese (Tokyo)A;G 0%
  • Yoruba (Nigeria)A;G 0%

Other HTR2A SNPs

All HTR2A SNPs

Notes

From SNPedia

Notes

Three (rs643627-rs594242-rs6311: A-C-T), two (rs594242-rs6311: C-T) and a single functional (rs6311: T) marker were protective against suicidal behavior. The complementary makers (rs594242-rs6311: G-C and rs6311: C) were associated with increased risk for non-violent and impulsive suicidal behavior. Furthermore, CC-homozygotes for the functional SNP rs6311 reported more anger- and aggression-related behavior. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Found that this is in linkage disequilibrium with rs655888.

Source and license

Adapted from rs643627 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.