rs6313
A SNP in the HTR2A gene on chromosome 13. Its most notable genotype is A;A: depression, panic, stress response
- Gene
- HTR2A
- Location
- Chr 1346,895,805 (GRCh38)
- Highest magnitude
- 2.1Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 43%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GBadhigher risk for RA
- A;GBadhigher risk for RA
- A;AMost notableBaddepression, panic, stress response
SNPedia records rs6313 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 33% A;G 48% A;A 19%
- European ancestry (Utah)G;G 27% A;G 52% A;A 20%
- Han Chinese (Beijing)G;G 23% A;G 45% A;A 33%
- Japanese (Tokyo)G;G 26% A;G 49% A;A 26%
- Yoruba (Nigeria)G;G 42% A;G 45% A;A 14%
- African ancestry (Southwest US)G;G 30% A;G 50% A;A 20%
- Chinese (Denver)G;G 14% A;G 55% A;A 31%
- Gujarati IndianG;G 37% A;G 50% A;A 14%
- Luhya (Kenya)G;G 48% A;G 43% A;A 9%
- Mexican ancestry (Los Angeles)G;G 36% A;G 52% A;A 12%
- Maasai (Kenya)G;G 56% A;G 39% A;A 6%
- TuscanG;G 23% A;G 52% A;A 26%
Related
Conditions, medicines and genes
Other HTR2A SNPs
- rs6311C;C3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants.Important
- rs6314G;Ghigher risk for RATypical
- rs594242C;GNo summary available.Typical
- rs643627A;GNo summary available.Typical
- rs659734A;Acommon in complete genomicsTypical
- rs1328674T;Thigher risk for RATypical
- rs2224721G;Gcommon/normalTypical
- rs7997012A;A~18% more likely to respond to citalopramTypical
Genosets
- Gs108Rheumatoid arthritis riskWorth knowing
- Gs109Rheumatoid arthritis risk; more stringent form of Gs108Worth knowing
- Gs226Novelty seeking behaviour potentialMinor
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 130 words
rs6313, also known as T102C, is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs6313(C). The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC. see also gs108 and gs226 Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder.
A;A
This variation in a serotonin receptor has several associations that relate to stress, depression, panic and personality.
Source and license
Adapted from rs6313 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.