rs594242
A SNP in the HTR2A gene on chromosome 13. Its most notable genotype is C;G.
- Gene
- HTR2A
- Location
- Chr 1346,883,917 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 13%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;G 14%
- European ancestry (Utah)C;G 27%
- Han Chinese (Beijing)C;G 4%
- Japanese (Tokyo)C;G 2%
- Yoruba (Nigeria)C;G 24%
Related
Other HTR2A SNPs
- rs6311C;C3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants.Important
- rs6313A;Adepression, panic, stress responseWorth knowing
- rs6314G;Ghigher risk for RATypical
- rs643627A;GNo summary available.Typical
- rs659734A;Acommon in complete genomicsTypical
- rs1328674T;Thigher risk for RATypical
- rs2224721G;Gcommon/normalTypical
- rs7997012A;A~18% more likely to respond to citalopramTypical
Notes
From SNPedia
Notes
Three (rs643627-rs594242-rs6311: A-C-T), two (rs594242-rs6311: C-T) and a single functional (rs6311: T) marker were protective against suicidal behavior. The complementary makers (rs594242-rs6311: G-C and rs6311: C) were associated with increased risk for non-violent and impulsive suicidal behavior. Furthermore, CC-homozygotes for the functional SNP rs6311 reported more anger- and aggression-related behavior.
Source and license
Adapted from rs594242 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.