rs6314
A SNP in the HTR2A gene on chromosome 13. Its most notable genotype is G;G: higher risk for RA
- Gene
- HTR2A
- Location
- Chr 1346,834,899 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 7%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableBadhigher risk for RA
- A;GBadhigher risk for RA; better response to paroxetine as treatment for depression
- A;ANot ratedaverage
SNPedia records rs6314 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageG;G 84% A;G 15% A;A 1%
- European ancestry (Utah)G;G 88% A;G 12% A;A 0%
- Han Chinese (Beijing)G;G 99% A;G <1% A;A 0%
- Japanese (Tokyo)G;G 100% A;G 0% A;A 0%
- Yoruba (Nigeria)G;G 67% A;G 31% A;A 2%
- African ancestry (Southwest US)G;G 79% A;G 19% A;A 2%
- Gujarati IndianG;G 94% A;G 6% A;A 0%
- Luhya (Kenya)G;G 78% A;G 19% A;A 3%
- Mexican ancestry (Los Angeles)G;G 88% A;G 12% A;A 0%
- Maasai (Kenya)G;G 60% A;G 34% A;A 6%
- TuscanG;G 88% A;G 11% A;A 1%
Related
Conditions, medicines and genes
Other HTR2A SNPs
- rs6311C;C3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants.Important
- rs6313A;Adepression, panic, stress responseWorth knowing
- rs594242C;GNo summary available.Typical
- rs643627A;GNo summary available.Typical
- rs659734A;Acommon in complete genomicsTypical
- rs1328674T;Thigher risk for RATypical
- rs2224721G;Gcommon/normalTypical
- rs7997012A;A~18% more likely to respond to citalopramTypical
Genosets
- Gs108Rheumatoid arthritis riskWorth knowing
- Gs109Rheumatoid arthritis risk; more stringent form of Gs108Worth knowing
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 230 words
rs6314, also known as C1354T or His452Tyr/H452Y, is a SNP in the serotonin 2A receptor HTR2A gene. Based on a study of 166 Caucasian patients being treated for depression with paroxetine, rs6314 heterozygotes were associated with better response. There was a significantly higher frequency of heterozygotes in the remitter and response groups in comparison to the non-remitter (odds ratio 7.50, p=0.002) and non-response groups (odds ratio 5.25, p=0.01). * rs6314 is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs6314(C). The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC. : "Haplotype association analysis suggests that the haplotype CCGCA (at SNPs rs3125, rs6314, rs1923886, rs2224721 and rs2770296) is protective against bipolar disorder (P = 0.021, odds ratio 0.63) and the rarer haplotype CCACG confers risk to the disorder (P = 0.0065, odds ratio 3.08)." Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families.
A;G
rheumatoid arthritis risk
Source and license
Adapted from rs6314 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.