rs6682654

A SNP in the CD244 gene on chromosome 1. Its most notable genotype is A;A.

Gene
CD244
Location
Chr 1160,839,213 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedNo summary available.Typical · 0.015% of people
  2. A;GBad1.34x increased risk for rheumatoid arthritisTypical · 0.045% of people
  3. G;GBad1.8x increased risk for rheumatoid arthritisTypical · 0.040% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 15% A;G 45% G;G 40%
  • European ancestry (Utah)A;A 34% A;G 54% G;G 12%
  • Han Chinese (Beijing)A;A 22% A;G 50% G;G 28%
  • Japanese (Tokyo)A;A 10% A;G 50% G;G 40%
  • Yoruba (Nigeria)A;A 1% A;G 25% G;G 74%
  • African ancestry (Southwest US)A;A 2% A;G 44% G;G 54%
  • Chinese (Denver)A;A 15% A;G 51% G;G 35%
  • Gujarati IndianA;A 21% A;G 49% G;G 30%
  • Luhya (Kenya)A;A 3% A;G 28% G;G 69%
  • Mexican ancestry (Los Angeles)A;A 30% A;G 51% G;G 19%
  • Maasai (Kenya)A;A 8% A;G 38% G;G 54%
  • TuscanA;A 19% A;G 54% G;G 28%

Conditions, medicines and genes

Other CD244 SNPs

All CD244 SNPs

Notes

From SNPedia

Notes

Two SNPs on ch 1q in the CD244 gene, rs3766379 and rs6682654, were found to be associated with risk for rheumatoid arthritis in two independent Japanese cohorts (p = 3.23 x 10e-8) and p = 7.45 x 10e-8). The odds ratio reported for the more common rs6682654(G) allele, as oriented in dbSNP and not the publication, was 1.34 (CI: 1.15-1.55, p = 0.0002).

Source and license

Adapted from rs6682654 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.