rs10499194

A SNP on chromosome 6. Its most notable genotype is T;T: protective against rheumatoid arthritis for asians

Gene
None listed
Location
Chr 6137,681,500 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormalTypical · 0.082% of people
  2. T;TMost notableGoodprotective against rheumatoid arthritis for asiansWorth knowing · 2.0<1% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 82% T;T <1%
  • European ancestry (Utah)C;C 66% T;T 2%
  • Han Chinese (Beijing)C;C 98% T;T 0%
  • Japanese (Tokyo)C;C 82% T;T 0%
  • Yoruba (Nigeria)C;C 81% T;T 0%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 170 words

rs10499194 associated with rheumatoid arthritis In a concurrent study, the Wellcome Trust Case Control Consortium (WTCCC) has reported strong association of rheumatoid arthritis susceptibility to a different SNP located 3.8 kb from rs10499194 (rs6920220; P = 5 x 10(-6) in WTCCC). We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23. rheumatoid arthritis *rs6920220 [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)]. *rs5029937 *rs13207033 protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with rs10499194 The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85)

T;T

No effect for caucasians.

References

Source and license

Adapted from rs10499194 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.