rs7528684
A SNP in the FCRL3 gene on chromosome 1. Its most notable genotype is G;G: 1.2x risk of Rheumatoid Arthritis; various risks of autoimmune diseases
- Gene
- FCRL3
- Location
- Chr 1157,701,026 (GRCh38)
- Highest magnitude
- 1.2Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 44%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGood0.73x reduced risk of Graves' disease
- A;GNot ratednormal
- G;GMost notableBad1.2x risk of Rheumatoid Arthritis; various risks of autoimmune diseases
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageA;A 18% A;G 34% G;G 47%
- European ancestry (Utah)A;A 25% A;G 53% G;G 22%
- Han Chinese (Beijing)A;A 35% A;G 46% G;G 20%
- Japanese (Tokyo)A;A 30% A;G 46% G;G 24%
- Yoruba (Nigeria)A;A 0% A;G 6% G;G 94%
- African ancestry (Southwest US)A;A 2% A;G 25% G;G 74%
- Chinese (Denver)A;A 40% A;G 44% G;G 16%
- Luhya (Kenya)A;A 0% A;G 10% G;G 90%
- Mexican ancestry (Los Angeles)A;A 26% A;G 47% G;G 26%
- Maasai (Kenya)A;A 0% A;G 19% G;G 81%
- TuscanA;A 26% A;G 47% G;G 28%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 360 words
SNP also known as "-169C/T" In a 2006 study, rs7528684 has been reported to be associated with rheumatoid arthritis in a Caucasian population, following reports of a similar association in a Japanese population. In this 2007 report, "FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians," The risk allele (oriented to the dbSNP entry) is (G) (which they report as C); the odds ratio associated with heterozygotes is 0.95 (CI 0.83-1.08), and for rs7528684 CC (GG) homozygotes, 2.30 (CI 1.64-3.23). But the "Meta-analysis of all studies comparing 9467 individuals showed that the OR for the CC (GG) genotype to develop RA was 1.2 and the p value <0.001." (Abstract) In a 2005 report, a summary indicates the following regarding disease and odds ratio (OR)for rs7528684 : * for rheumatoid arthritis: OR = 2.15 (CI = 1.58–2.93), from 830 cases and 658 controls; * for SLE: OR = 1.49 (CI = 1.16–1.92), from 564 cases; * for Graves' disease : OR = 1.79 (CI = 1.34–2.39), from 351 cases; * for Hashimoto thyroiditis: OR = 1.62 (CI = 1.07–2.47), from 158 cases. rs7528684 rs3792876 and rs2268277 failed to showed a statistically significant association with rheumatoid arthritis rs7528684, rs11264799, rs945635 and rs3761959 were not associated with systemic lupus erythematosus (SLE) in a study of 248 Chinese Han patients. In a 2008 study of 645 Caucasians from Southern Spain with multiple sclerosis, the rs7528684(G) allele (in dbSNP orientation) was found to be somewhat protective (per allele odds ratio 0.81, CI: 0.70-0.94, p=0.007). Found the AA genotype of PTPN22 rs3789604 and AA genotype of FCRL3 rs7528684 to be protective against Graves' by OD 0.73. Not on PubMed, (but at 10.1111/j.1464-5491.2006.01848), a 2006 article titled "The functional variant –169C/T in the FCRL3 gene does not increase susceptibility to Type 1 diabetes" found no associations between this SNP's various allele combinations and Type 1 Diabetes in a Finnish population (735 cases and 735 non-diabetic healthy controls)
A;A
according to PMID 19438904
Source and license
Adapted from rs7528684 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.