rs6457617

A SNP on chromosome 6. Its most notable genotype is T;T: 5.2x risk of rheumatoid arthritis

Gene
None listed
Location
Chr 632,696,074 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.021% of people
  2. C;TBad2.3x risk of rheumatoid arthritisWorth knowing · 2.049% of people
  3. T;TMost notableBad5.2x risk of rheumatoid arthritisWorth knowing · 2.130% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 21% C;T 49% T;T 30%
  • European ancestry (Utah)C;C 22% C;T 51% T;T 27%
  • Han Chinese (Beijing)C;C 24% C;T 46% T;T 30%
  • Japanese (Tokyo)C;C 15% C;T 47% T;T 38%
  • Yoruba (Nigeria)C;C 31% C;T 51% T;T 18%
  • African ancestry (Southwest US)C;C 27% C;T 36% T;T 38%
  • Chinese (Denver)C;C 14% C;T 58% T;T 28%
  • Gujarati IndianC;C 25% C;T 57% T;T 18%
  • Luhya (Kenya)C;C 17% C;T 50% T;T 33%
  • Mexican ancestry (Los Angeles)C;C 7% C;T 41% T;T 52%
  • Maasai (Kenya)C;C 28% C;T 50% T;T 22%
  • TuscanC;C 20% C;T 50% T;T 30%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs6457617 has been reported in a large study to be associated with rheumatoid arthritis. This SNP is reported to be the most statistically significant of many SNPs similarly located in the MHC region. Tag-snp for HLA-DQA1*03. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 2.36 (CI 1.97-2.84), and for homozygotes, 5.21 (CI 4.31-6.30).

Source and license

Adapted from rs6457617 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.