rs6684865

A SNP in the MMEL1 gene on chromosome 1. Its most notable genotype is A;A: 1.5x risk of rheumatoid arthritis

Gene
MMEL1
Location
Chr 12,614,790 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
42%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.5x risk of rheumatoid arthritisTypical · 0.022% of people
  2. A;GBad1.2x risk of rheumatoid arthritisTypical · 0.049% of people
  3. G;GNot ratednormalTypical · 0.029% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 22% A;G 49% G;G 29%
  • European ancestry (Utah)A;A 12% A;G 42% G;G 46%
  • Han Chinese (Beijing)A;A 23% A;G 58% G;G 19%
  • Japanese (Tokyo)A;A 22% A;G 52% G;G 26%
  • Yoruba (Nigeria)A;A 32% A;G 50% G;G 18%
  • African ancestry (Southwest US)A;A 26% A;G 49% G;G 25%
  • Chinese (Denver)A;A 28% A;G 54% G;G 18%
  • Gujarati IndianA;A 20% A;G 50% G;G 31%
  • Luhya (Kenya)A;A 31% A;G 46% G;G 24%
  • Mexican ancestry (Los Angeles)A;A 16% A;G 47% G;G 38%
  • Maasai (Kenya)A;A 28% A;G 48% G;G 24%
  • TuscanA;A 5% A;G 41% G;G 54%

Conditions, medicines and genes

Other MMEL1 SNPs

All MMEL1 SNPs

Notes

From SNPedia

Notes

rs6684865 has been reported in a large study to be associated with rheumatoid arthritis. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.27 (CI 1.02-1.56), and for homozygotes, 1.54 (CI 1.25-1.90).

Source and license

Adapted from rs6684865 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.