rs3890745

A SNP in the MMEL1 gene on chromosome 1. Its most notable genotype is T;T: 1.12x risk of Rheumatoid arthritis

Gene
MMEL1
Location
Chr 12,622,185 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
43%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.12x risk of Rheumatoid arthritisTypical · 0.028% of people
  2. C;TGoodNo summary available.Typical · 0.048% of people
  3. C;CGood0.79x Reduced risk of RATypical · 0.024% of people

SNPedia records rs3890745 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 28% C;T 48% C;C 24%
  • European ancestry (Utah)T;T 46% C;T 42% C;C 12%
  • Han Chinese (Beijing)T;T 19% C;T 58% C;C 23%
  • Japanese (Tokyo)T;T 26% C;T 52% C;C 22%
  • Yoruba (Nigeria)T;T 18% C;T 48% C;C 35%
  • African ancestry (Southwest US)T;T 21% C;T 47% C;C 32%
  • Chinese (Denver)T;T 18% C;T 54% C;C 28%
  • Gujarati IndianT;T 32% C;T 53% C;C 16%
  • Luhya (Kenya)T;T 19% C;T 36% C;C 45%
  • Mexican ancestry (Los Angeles)T;T 38% C;T 47% C;C 16%
  • Maasai (Kenya)T;T 17% C;T 50% C;C 33%
  • TuscanT;T 54% C;T 41% C;C 5%

Other MMEL1 SNPs

All MMEL1 SNPs

Notes

From SNPedia

Notes

C;C

Strongest association was detected for rs3890745 (p=2.6×10 −5 unadjusted, p=0.003 adjusted, OR=0.79, 95% CI 0.71 to 0.88) for minor allele G. (Danoy et al.)

Source and license

Adapted from rs3890745 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.