rs9268839

A SNP in the HLA-DRB9 gene on chromosome 6. Its most notable genotype is G;G: Moderately (~4x) increased rheumatoid arthritis risk (in Caucasians)

Gene
HLA-DRB9
Location
Chr 632,460,995 (GRCh38)
Highest magnitude
2.9Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.0
  2. A;GBad2x increase in rheumatoid arthritis risk (in Caucasians)Worth knowing · 2.0
  3. G;GMost notableBadModerately (~4x) increased rheumatoid arthritis risk (in Caucasians)Worth knowing · 2.9

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs9268839(G) was the variant most strongly associated in Europeans with risk for rheumatoid arthritis in this GWAS study of ~30,000 patients (OR 2.47, CI: 2.39-2.55, p = 1.5 × 10−e300).

A;G

see text and links via main rs-page

G;G

see text and links via main rs-page

Source and license

Adapted from rs9268839 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.