rs3761847

A SNP in the TRAF1 gene on chromosome 9. Its most notable genotype is G;G: >1.32 x risk of rheumatoid arthritis

Gene
TRAF1
Location
Chr 9120,927,961 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
48%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalTypical · 0.025% of people
  2. A;GBad1.32 x risk of rheumatoid arthritis.Worth knowing · 2.150% of people
  3. G;GMost notableBad>1.32 x risk of rheumatoid arthritisWorth knowing · 2.225% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 25% A;G 50% G;G 25%
  • European ancestry (Utah)A;A 25% A;G 55% G;G 20%
  • Han Chinese (Beijing)A;A 29% A;G 50% G;G 20%
  • Japanese (Tokyo)A;A 30% A;G 50% G;G 20%
  • Yoruba (Nigeria)A;A 12% A;G 57% G;G 31%
  • African ancestry (Southwest US)A;A 26% A;G 54% G;G 19%
  • Chinese (Denver)A;A 22% A;G 60% G;G 18%
  • Gujarati IndianA;A 51% A;G 42% G;G 8%
  • Luhya (Kenya)A;A 5% A;G 41% G;G 55%
  • Mexican ancestry (Los Angeles)A;A 28% A;G 55% G;G 17%
  • Maasai (Kenya)A;A 14% A;G 42% G;G 44%
  • TuscanA;A 37% A;G 44% G;G 19%

Conditions, medicines and genes

Other TRAF1 SNPs

All TRAF1 SNPs

Notes

From SNPedia

Show notes, about 240 words

rs3761847, a SNP located between two genes associated with chronic inflammation (TRAF1 and C5), is associated with increased risk of anti CCP-positive rheumatoid arthritis. The risk allele is (G); the odds ratio reported is 1.32 (95% confidence interval, 1.23 to 1.42; P=4x10-14) . rs3761847(G;G) associated with an increased risk of death (hazard ratio 3.96 [95% confidence interval 1.24-12.6], P = 0.020) as compared with (A;A) homozygote status. The excess mortality was attributed to deaths due to malignancies and sepsis but not cardiovascular disease (CVD).

A;G

A common genetic variant at the TRAF1-C5 locus on chromosome 9 is associated with an increased risk of anti-CCP-positive rheumatoid arthritis. rs3761847, a SNP located between two genes associated with chronic inflammation (TRAF1 and C5), is associated with increased risk of anti CCP-positive rheumatoid arthritis. The risk allele is (G); the odds ratio reported is 1.32 (95% confidence interval, 1.23 to 1.42; P=4x10-14) PMID 17804836.

G;G

A common genetic variant at the TRAF1-C5 locus on chromosome 9 is associated with an increased risk of anti-CCP-positive rheumatoid arthritis. rs3761847, a SNP located between two genes associated with chronic inflammation (TRAF1 and C5), is associated with increased risk of anti CCP-positive rheumatoid arthritis. The risk allele is (G); the odds ratio reported is 1.32 (95% confidence interval, 1.23 to 1.42; P=4x10-14) PMID 17804836.

References

Source and license

Adapted from rs3761847 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.