rs729302

A SNP on chromosome 7. Its most notable genotype is A;C: 0.89x decreased risk of developing rheumatoid arthritis

Gene
None listed
Location
Chr 7128,928,906 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
27%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABadNormal risk of developing rheumatoid arthritisMinor · 1.054% of people
  2. A;CMost notableGood0.89x decreased risk of developing rheumatoid arthritisMinor · 1.538% of people
  3. C;CGood0.89x decreased risk of developing rheumatoid arthritisMinor · 1.57% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 54% A;C 38% C;C 7%
  • European ancestry (Utah)A;A 46% A;C 46% C;C 8%
  • Han Chinese (Beijing)A;A 37% A;C 46% C;C 18%
  • Japanese (Tokyo)A;A 57% A;C 39% C;C 4%
  • Yoruba (Nigeria)A;A 71% A;C 27% C;C 1%
  • African ancestry (Southwest US)A;A 56% A;C 35% C;C 9%
  • Chinese (Denver)A;A 38% A;C 50% C;C 13%
  • Gujarati IndianA;A 49% A;C 39% C;C 13%
  • Luhya (Kenya)A;A 62% A;C 36% C;C 2%
  • Mexican ancestry (Los Angeles)A;A 64% A;C 29% C;C 7%
  • Maasai (Kenya)A;A 67% A;C 31% C;C 2%
  • TuscanA;A 53% A;C 41% C;C 6%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A variant located 64 bp upstream of the first untranslated exon (exon 1A), consisting of a 5 bp insertion/deletion CGGGG, may be the causative SNP in this region that is most responsible for increasing SLE risk, however it lacks an rs# (i.e. it isn't registered in dbSNP). A meta-analysis comprising 5 case-control studies, totaling 6,582 rheumatoid arthritis cases and 5,375 controls, concluded that several IRF5 gene SNPs were indeed (still) significantly associated with the disease. The rs729302(C) allele was associated with a slight protective effect (odds ratio 0.89, CI: 0.8-0.977, p = 0.015).

Source and license

Adapted from rs729302 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.