rs11162922

A SNP on chromosome 1. Its most notable genotype is A;A: 2x risk

Gene
None listed
Location
Chr 180,106,373 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2x riskTypical · 0.060% of people
  2. A;GBad1.3x riskTypical · 0.035% of people
  3. G;GNot ratednormalTypical · 0.05% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 60% A;G 35% G;G 5%
  • European ancestry (Utah)A;A 87% A;G 13% G;G 0%
  • Han Chinese (Beijing)A;A 56% A;G 39% G;G 5%
  • Japanese (Tokyo)A;A 53% A;G 39% G;G 8%
  • Yoruba (Nigeria)A;A 51% A;G 43% G;G 6%
  • African ancestry (Southwest US)A;A 53% A;G 40% G;G 7%
  • Chinese (Denver)A;A 45% A;G 49% G;G 6%
  • Gujarati IndianA;A 69% A;G 27% G;G 4%
  • Luhya (Kenya)A;A 43% A;G 51% G;G 6%
  • Mexican ancestry (Los Angeles)A;A 79% A;G 21% G;G 0%
  • Maasai (Kenya)A;A 39% A;G 49% G;G 12%
  • TuscanA;A 80% A;G 19% G;G 1%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs11162922 has been reported in a large study to be associated with rheumatoid arthritis. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.27 (CI 0.41-4.01), and for homozygotes, 2.00 (CI 0.64-6.20).

Source and license

Adapted from rs11162922 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.