rs9550642

A SNP in the LOC100133618 gene on chromosome 13. Its most notable genotype is A;A: 2.2x risk

Gene
LOC100133618
Location
Chr 1320,375,953 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2.2x riskTypical · 0.04% of people
  2. A;GBad1.3x riskTypical · 0.022% of people
  3. G;GGoodnormalTypical · 0.073% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 4% A;G 22% G;G 73%
  • European ancestry (Utah)A;A <1% A;G 18% G;G 81%
  • Han Chinese (Beijing)A;A 8% A;G 47% G;G 45%
  • Japanese (Tokyo)A;A 18% A;G 50% G;G 33%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • African ancestry (Southwest US)A;A 0% A;G 18% G;G 83%
  • Chinese (Denver)A;A 13% A;G 39% G;G 48%
  • Gujarati IndianA;A 9% A;G 40% G;G 52%
  • Luhya (Kenya)A;A 0% A;G 2% G;G 98%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 12% G;G 88%
  • Maasai (Kenya)A;A 0% A;G 5% G;G 96%
  • TuscanA;A 0% A;G 18% G;G 82%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs9550642 has been reported in a large study to be associated with rheumatoid arthritis. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.34 (CI 1.15-1.56), and for homozygotes, 2.23 (CI 1.21-4.13).

Source and license

Adapted from rs9550642 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.