rs2837960

A SNP in the LINC00323 gene on chromosome 21. Its most notable genotype is G;G: 2.3x rheumatoid arthritis risk

Gene
LINC00323
Location
Chr 2141,139,991 (GRCh38)
Highest magnitude
2.3Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad2.3x rheumatoid arthritis riskWorth knowing · 2.35% of people
  2. G;TNot ratednormalTypical · 0.034% of people
  3. T;TNot ratednormalTypical · 0.060% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 5% G;T 34% T;T 60%
  • European ancestry (Utah)G;G 2% G;T 26% T;T 73%
  • Han Chinese (Beijing)G;G 5% G;T 29% T;T 66%
  • Japanese (Tokyo)G;G <1% G;T 23% T;T 76%
  • Yoruba (Nigeria)G;G 10% G;T 45% T;T 46%
  • African ancestry (Southwest US)G;G 9% G;T 53% T;T 39%
  • Chinese (Denver)G;G 5% G;T 30% T;T 65%
  • Gujarati IndianG;G 4% G;T 31% T;T 65%
  • Luhya (Kenya)G;G 8% G;T 59% T;T 33%
  • Mexican ancestry (Los Angeles)G;G 0% G;T 12% T;T 88%
  • Maasai (Kenya)G;G 14% G;T 41% T;T 46%
  • TuscanG;G 4% G;T 29% T;T 67%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

rs2837960 has been reported in a large study to be associated with rheumatoid arthritis. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 0.95 (CI 0.83-1.08), and for homozygotes, 2.30 (CI 1.64-3.23). Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis. AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm.

G;G

The risk allele is (G); the odds ratio associated with homozygotes (G;G) is 2.30 (CI 1.64-3.23). PMID 17554300

References

Source and license

Adapted from rs2837960 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.