rs1953126

A SNP in the PHF19 gene on chromosome 9. Its most notable genotype is C;C: normal

Gene
PHF19
Location
Chr 9120,878,222 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.048% of people
  2. C;TNot rated1.3x increased risk for rheumatoid arthritisTypical · 0.043% of people
  3. T;TNot rated1.3x increased risk for rheumatoid arthritisTypical · 0.09% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 48% C;T 43% T;T 9%
  • European ancestry (Utah)C;C 39% C;T 45% T;T 16%
  • Han Chinese (Beijing)C;C 42% C;T 48% T;T 10%
  • Japanese (Tokyo)C;C 51% C;T 44% T;T 4%
  • Yoruba (Nigeria)C;C 54% C;T 40% T;T 5%
  • African ancestry (Southwest US)C;C 60% C;T 37% T;T 4%
  • Chinese (Denver)C;C 42% C;T 49% T;T 9%
  • Gujarati IndianC;C 66% C;T 28% T;T 6%
  • Luhya (Kenya)C;C 58% C;T 36% T;T 6%
  • Mexican ancestry (Los Angeles)C;C 40% C;T 50% T;T 10%
  • Maasai (Kenya)C;C 37% C;T 49% T;T 15%
  • TuscanC;C 42% C;T 43% T;T 15%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A study of 475 Caucasian patients concluded that rs1953126, on chromosome 9q33.2, was significantly associated with rheumatoid arthritis (odds ratio 1.28, CI 1.16–1.40, trend p comb = 1.45e-06).

Source and license

Adapted from rs1953126 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.