rs33996649

A SNP in the PTPN22 gene on chromosome 1. Its most notable genotype is T;T: Slightly lower (~0.65x) risk for rheumatoid arthritis

Gene
PTPN22
Location
Chr 1113,852,067 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in complete genomicsTypical · 0.0
  2. C;TGoodSlightly lower (~0.8x) risk for rheumatoid arthritisMinor · 1.2
  3. T;TMost notableGoodSlightly lower (~0.65x) risk for rheumatoid arthritisMinor · 1.6

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other PTPN22 SNPs

All PTPN22 SNPs

Notes

From SNPedia

Notes

rs33996649, also known as c.788G>A, Arg263Gln and R263Q, represents a variant in the PTPN22 gene located on chromosome 1. Some studies have linked the minor allele of this SNP to slightly reduced risk for several autoimmune diseases such as Crohn's disease, ulcerative colitis and rheumatoid arthritis. PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. A PTPN22 promoter polymorphism -1123G>C is associated with RA pathogenesis in Chinese. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples.

Source and license

Adapted from rs33996649 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.