rs1310182

A SNP in the PTPN22 gene on chromosome 1. Its most notable genotype is G;G: common/normal

Gene
PTPN22
Location
Chr 1113,830,881 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon/normalTypical · 0.0
  2. A;AGoodcommon/normalTypical · 0.0

SNPedia records rs1310182 on the minus strand: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other PTPN22 SNPs

All PTPN22 SNPs

Notes

From SNPedia

Show notes, about 160 words

PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes. Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. Meta-genetic association of rheumatoid arthritis and PTPN22 using PedGenie 2.1. Comparing strategies for evaluation of candidate genes in case-control studies using family data. Case-control association analysis of rheumatoid arthritis with candidate genes using related cases. Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis. A PTPN22 promoter polymorphism -1123G>C is associated with RA pathogenesis in Chinese. No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations.

Source and license

Adapted from rs1310182 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.