rs6920220

rs6920220 has been reported in a large study to be associated with rheumatoid arthritis. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.20 (CI 1.06-1.36), and for homozygotes, 1.72 (CI 1.33-2.22). rheumatoid arthritis *rs6920220 [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)]. *rs5029937 *rs13207033 protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with rs10499194 The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85) Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Rheumatoid arthritis: a view of the current genetic landscape. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations. Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility. 6q23 polymorphisms in rheumatoid arthritis Spanish patients. Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations. Complex genetic association of 6q23 with autoimmune rheumatic conditions. Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls. Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis. Conditional analysis of the major histocompatibility complex in rheumatoid arthritis. Lack of association between the rs6920220 (G/A) polymorphism of the 6q23 region and biopsy-proven giant cell arteritis. Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm. Genetic variants in the prediction of rheumatoid arthritis. Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment. Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population. Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. A Tunisian case-control association study of a 6q polymorphism in rheumatoid arthritis. Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.