rs11761231

A SNP on chromosome 7. Its most notable genotype is A;A.

Gene
None listed
Location
Chr 7131,685,280 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. C;CNot ratedNo summary available.Typical · 0.037% of people
  3. C;TNot ratedNo summary available.Typical · 0.040% of people
  4. T;TNot ratednormalTypical · 0.024% of people

On SNPedia: (A;A), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 0% C;C 37% C;T 40% T;T 24%
  • European ancestry (Utah)A;A 0% C;C 37% C;T 44% T;T 19%
  • Han Chinese (Beijing)A;A 0% C;C 7% C;T 41% T;T 53%
  • Japanese (Tokyo)A;A 0% C;C 9% C;T 47% T;T 44%
  • Yoruba (Nigeria)A;A 0% C;C 67% C;T 31% T;T 2%
  • African ancestry (Southwest US)A;A 0% C;C 51% C;T 42% T;T 7%
  • Chinese (Denver)A;A 0% C;C 8% C;T 29% T;T 63%
  • Gujarati IndianA;A 0% C;C 31% C;T 43% T;T 27%
  • Luhya (Kenya)A;A 0% C;C 60% C;T 36% T;T 5%
  • Mexican ancestry (Los Angeles)A;A 0% C;C 31% C;T 41% T;T 28%
  • Maasai (Kenya)A;A 0% C;C 56% C;T 41% T;T 3%
  • TuscanA;A 0% C;C 45% C;T 41% T;T 14%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 150 words

rs11761231 has been reported in a large study to be associated with rheumatoid arthritis, particularly in females. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.44 (CI 1.19-1.75), and for homozygotes, 1.64 (CI 1.35-1.99). The association between rs11761231 and rheumatoid arthritis did not reproduce in a North American population, emphasizing "the need to carefully account for population structure to avoid false-positive disease associations". Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls. Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.

Source and license

Adapted from rs11761231 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.